Giant condyloma acuminatum or Buschke–Löwenstein tumor

Last Updated: 2019-08-27

Author(s): Anzengruber F., Navarini A.

ICD11: -

Buschke u. Löwenstein 1925

Buschke-Löwenstein-Tumor, Verrucous carcinoma of the genital region, giant condyloma, Condyloma acuminatum giganteum; Carcinoma verrucosum.

Giant form of Condylomata acuminata, which is already classified as a carcinoma. Both the anal region and the genital region can be affected.

More common in men than in women.

The Condylomata gigantea are mostly triggered by HPV 6, 11 and 56.

Massively exophytic, skin-coloured, cauliflower-like tumours.

Clinical diagnosis.

Genitoanal area.

The exophytic tissue masses tend to interfere with sexual intercourse and defecation.

Transformation into spinocellular carcinoma occurs.

Patients often do not know that condoms only protect the skin from infections that are also covered by them.

Recurrence possible. Close-meshed aftercare.

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Surgical removal with post-treatment by Imiquimod (Aldara®).

Aldara® 3x a week for 12 weeks. .
- off-label-use:
  - Individ. 5x/ week over several weeks, maximum 16 weeks.
  - The wart surface must be removed beforehand.
  - Side effects: redness, itching, burning, erosion of the skin. Inform Pat. about this before starting therapy!

In individual cases the monotherapy of Aldara® (Imiquimod) cream and CO² laser is described

Grassegger A, Hopfl R, Hussl H, Wicke K, Fritsch P. Buschke—Loewenstein tumour infiltrating pelvic organs. Br J Dermatol 1994;130:221-5.
Qian G, Yu H. Giant condyloma acuminata of Buschke-Lowenstein: successful treatment mainly by an innovative surgical method. Dermatologic Therapy 2013:n/a-n/a.
Schwartz RA. Buschke-Loewenstein tumor: Verrucous carcinoma of the penis. Journal of the American Academy of Dermatology 1990;23:723-7.

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