Lichen ruber planus

Last Updated: 2023-07-07

Author(s): Anzengruber F., Navarini A.

ICD11: EA91.Z

Wilson, 1869

Lichen ruber, lichen planus.

Pruritic, non-contagious, subacute to chronic, self-limiting (but often lasting for years) disease of the skin and/or mucous membranes.

  • Prevalence: 0.2%-1.0% of the (adult) population
  • Up to 25% of patients have isolated lichen planus of the mucosa
  • Familial lichen planus is rare
  • Most common between 30-60 yrs, rare in children
  • Women = men
  • No ethnic predisposition

  • Lichen ruber planus (classic form)
  • Lichen ruber integumentalis
  • Lichen ruber anularis
  • Lichen ruber linearis
  • Blaschkoider lichen planus
  • Zosteriform lichen planus
  • Lichen ruber verrucosus
  • Lichen planus hypertrophicus
  • Lichen ruber atrophicans
  • Lichen planus pigmentosus
  • Lichen ruber vesiculosus et bullosus
  • Lichen ruber pemphigoides
  • Lichen ruber actinicus
  • Lichen planus exanthematicus
  • Erythrodermic lichen planus
  • Inverse lichen planus
  • Lichen ruber of the mucous membranes
    • Lichen planus mucosae
    • Lichen planus genitalis
  • Lichen ruber of the skin appendages
    • Lichen ruber follicularis (lichen planopilaris)
    • Lichen ruber of the nails
    • Lichen ruber of the palms and soles

  • Not yet fully understood. CD8+ T-cells cause apoptosis of keratinocytes.
  • Approximately 100 cases of familial occurrence have been described
  • Associations
    • Autoimmune diseases
      • Ulcerative colitis
      • Crohn's disease
      • Alopezia areata
      • Vitiligo
      • Dermatomyositis
      • Myastenia gravis
      • Pemphigus vulgaris
      • Bullous pemphigoid
      • Lupus erythematosus
    • Viral infections
    • Medications
      • Antiarthritics
        • Gold compounds
        • D-penicillamine
      • Antibiotics
        • Streptomycin
        • Tetracyclines
      • Anti-diabetics
        • Sulfonylureas
        • Glimepiride
      • Antileprosa
        • Dapsone
      • Antimalarials
        • Chloroquine
        • Hydroxychloroquine
        • Chinine
      • Antipsychotics
        • Levomepromazine
        • Amitriptyline
        • Carbamazepine
      • Diuretics
        • Hydrochlorothiazide
        • Furosemide
        • Spironolactone
      • Tuberculostatics
        • Paraaminosalicylic acid
        • Isoniazide
      • Antihypertensives
        • β-blockers
        • Calcium antagonists
        • ACE inhibitors
      • Antiphlogistics
        • ASS
        • Ibuprofen
        • Naproxen
      • Lipid reducer
        • Simvastatin
        • Pravastatin
    • Mechanical trauma (Köbner phenomenon)
    • Chronic graft-versus-host disease (GVHD)
    • Metabolic diseases
      • Diabetes mellitus
      • Hypercholesterolaemia
      • Hyperuricaemia
    • Liver diseases
      • Chronic active hepatitis
      • Primary biliary cirrhosis
    • Contact allergens
    • Paraneoplasia

Particularly on the flexors of the wrists and forearms, on the lateral ankles, sharply demarcated, erythematous, lichenoid, polygonal, lacquer-like shiny, partly confluent papules and plaques appear. Often a whitish reticulation (wickham's pattern) can be seen. A characteristic feature of cutaneous primary efflorescences is the surface reflection, which is best recognised when the light is incident from the side. Exanthematous spreading may occur in the course. As a rule, the efflorescences flatten out again after months. Hyperpigmentation develops especially in dark-skinned patients.

  • Wickham's drawing/ Wickham's phenomenon/ Wickham's stiffening: whitish reticulation on the primary efflorescences. This is often particularly visible around the mucous membranes. In patients with dark skin colour, the Wickham's pattern is often absent
  • Köbner phenomenon: isomorphic stimulus effect triggered by mechanical, thermal or chemical triggers, which triggers a linear arrangement of primary efflorescences. This arises from manipulating / scratching the patient due to the lesional pruritus.
  • Palmoplantar as well as lateral edges: Hyperkeratotic, whitish-yellowish plaques with erythematous margins may be visible.
  • Nails:
    • Rarely isolated infestation
    • Dystrophy, atrophy, spotted nails, longitudinal striations (erythronychia), pterygia, subungual keratoses, onychoschisis
    • Partial or complete destruction of the nail possible
  • Capillitium:
    • Lichen planus follicularis capillitii
      • Pruritic, chronically stationary rather blurred, sometimes hyperkeratotic erythema. Sometimes tufts of hair are seen. Characteristic is the scarring arising from the erythema.
    • Lichen planopillaris
      • Diffuse disseminated follicular-bound erythema, which changes to hyperkeratotic papules up to 1 cm in diameter. In the course, these lesions may also become atrophic or scarring.
  • A keratosis follicularis is partly visible on the upper arms or thighs
  • Ulerythema ophryogenes is a follicular hyperkeratosis and vasodilatation of the eyebrows. In the course, follicular atrophy may occur
  • Mucosal involvement (lichen planus mucosae): Wickham's stiffening is usually clearly visible here. In addition, whitish, nummular papules and plaques may also be visible
    • In erosive lichen planus mucosae, there is an increased tendency to malignancy
    • Lichen planus vulvae is characterised by an anular or circular form

  • Anamnesis
    • Medication intake?
  • Clinical picture
  • Biopsy
    • Dermatopathology
    • Direct immunofluorescence (usually not necessary in practice, but often characteristic)
  • Laboratory
    • AST, ALT, γ-GT, cholesterol, uric acid, haemoccult

  • Mucous membranes (oral and genital mucosa)
  • Nails
  • Capillitium: lichen planopilaris

  • Interface dermatitis with sawtooth-like acanthosis, orthohyperkeratosis and hypergranulosis. Lymphoid cellular, epidermotropic infiltrate, predominantly consisting of CD8-positive T cells.
  • Direct immunofluorescence
    • Subepithelial, ribbon-like fibrin deposits. Cytoid corpuscles load with IgG, IgM, C3 in epithelium and str. papillare.

  • Evolution of squamous cell carcinoma
    • V.a. in erosive or verrucous forms
  • Scarring alopecia

Mostly spontaneous healing within 1-2 years, but there are also chronic courses.

  1. Kaposi M. Noch einmal: Lichen ruber acuminatus und Lichen ruber planus. Arch f Dermat 1895;31:1-32. 
  2.  Mehregan AH, Heath LE, Pinkus H. Lichen ruber moniliformis and lichen ruber verrucosus et reticularis of Kaposi. J Cutan Pathol 1984;11:2-11. 
  3.  Behzad M, Michl C, Arweiler N, Pfützner W. Kontaktallergische lichenoide Reaktion auf Eugenol unter dem Bild eines Lichen ruber mucosae. Allergo Journal 2014;23:14-7. 
  4.  Lebwohl, Mark. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. Elsevier, 2014. Print.