Chronic mucocutaneous candidiasis
Last Updated: 2020-08-12
Author(s): Anzengruber F., Navarini A.
Candidosis, chronic mucocutaneous, CMC.
Group of persistent diseases characterized by Candida infection of the skin and mucous membrane.
Often starts with children.
- In chronic mucocutaneous candidiasis, various causative factors may be involved.
- In most cases, the infection occurs in disorders of the immune system (thymus aplasia, agammaglobulinemia, malignant lymphomas, Hodgkin's disease, malignant tumours, immunosuppressants, hypoparathyroidism, hypoadrenocorticism and iron deficiency).
- A genetic association can be assumed due to increased familial occurrence
- Simultaneous occurrence of several candidoses (candidosis of the oral mucosa including larynx and oesophagus, perlèche, vulvovaginal candidosis, intertriginous candidosis, paronychia candidamycetica- see respective underlying disease) simultaneously.
- In addition, eye diseases (blepharitis and conjunctivitis), urethritis, hematuria, urethrastricture, cystitis, diarrhea, multiple endocrinological disorders, chronic rhinitis, chronic recurrent pneumonia, pulmonary fibrosis and spontaneous pneumothorax may occur.
- The granulomatous inflammatory reaction is often very pronounced.
- Family history.
- Clinical features.
- Myco. -smears (native and culture).
- Biopsy, if necessary.
Chronic recurrent course.
- Kirkpatrick CH. Chronic mucocutaneous candidiasis. The Pediatric Infectious Disease Journal 2001;20:197-206.
- Puel A, Döffinger R, Natividad A, et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. The Journal of Experimental Medicine 2010;207:291-7.