Chronic mucocutaneous candidiasis
Last Updated: 2023-09-28
Author(s): Anzengruber F., Navarini A.
Candidiasis, chronic mucocutaneous, CMC.
Group of persistent diseases characterised by Candida infection of the skin and mucous membrane.
Often starts with children.
- Different causative factors may be involved in chronic mucocutaneous candidiasis
- The infection usually occurs in the presence of immune disorders (thymic aplasia, agammaglobulinemia, malignant lymphoma, Hodgkin's disease, malignant tumours, immunosuppressants, hypoparathyroidism, hypoadrenocorticism and iron deficiency)
- Because of increased familial occurrence, a genetic association can be assumed
- Simultaneous occurrence of several candidoses (candidiasis of the oral mucosa incl. larynx and oesophagus, perlèche, vulvovaginal candidiasis, intertriginous candidiasis, paronychia candidamycetica - see respective underlying disease)
- Furthermore, eye diseases (blepharitis and conjunctivitis), urethritis, haematuria, urethral strictures, cystitis, diarrhoea, multiple endocrinological disorders, chronic rhinitis, chronic recurrent pneumonia, pulmonary fibrosis and spontaneous pneumothorax can occur.
- The granulomatous inflammatory reaction is often very pronounced.
- Family history
- Myco. smears (native and culture)
- Biopsy if necessary
Chron. rec. Course.
- Kirkpatrick CH. Chronic mucocutaneous candidiasis. The Pediatric Infectious Disease Journal 2001;20:197-206.
- Puel A, Döffinger R, Natividad A, et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. The Journal of Experimental Medicine 2010;207:291-7.