Condylomata plana

Last Updated: 2019-08-27

Author(s): Anzengruber F., Navarini A.

ICD11: -

HPV 16 and 18-associated precursors of intraepithelial neoplasias in the genitoanal region from vulva to cervix. Flat condylomata acuminata.a.

Skin-coloured, sharply defined, relatively flat (only discreetly raised) papules and plaques with a disruptive surface.

  • Clinic
  • Acetic acid test 5%

Mostly the cervix uteri and the prepuce.

Partner should be examined by a doctor in any case!

Inform patients about the ping-pong phenomenon, which stands for reinfection by the untreated partner. Therefore, both partners should be treated simultaneously.

 

Topical therapy (mostly off label use!)

Cryotherapy

Aperture: 2x to 15 seconds.

Note: effective, cheap, short-term unpleasant for patients.

 

Immunomodulators

Imiquimod

Aldara® 3x a week for 12 weeks.

Off-label-use:

Individ. 5x/ week over several weeks, maximum 16 weeks.

The wart surface must be removed beforehand.

Side effects: redness, itching, burning, erosion of the skin. Inform Pat. about this before starting therapy!

Podophyllin/podophyllotoxin

Condyline® Lin: Apply 2x daily for 3 consecutive days. Repeat if necessary.

Off-label-use:

Application: Apply 2x daily for 3 consecutive days, protect surrounding skin. Repeat if necessary.

AI: < 12 years, open wounds, women of childbearing age, contraception recommended up to 30 days after therapy, pregnancy, lactation.

 

Sinecatechins (Veregen® - Ointment) Green Tea Extract

Application: 3x daily for up to 16 weeks.

 

Trichloroacetic acid 85% (Magistral formulation)

Application: 1x/ week with cotton swabs. Therapy belongs in the hands of a doctor. Also allowed during pregnancy, in case of overdose neutralization with sodium bicarbonatesg.

 

Removal with CO² laser/electrocution/curette/excision:

CAVE infectivity! Especially when laser cutting and electro chewing. Always wear a face mask or goggles and mouthguard! Smoke extraction is essential.

 

Other described therapies:

Interferon- β Gel application should be carried out for a maximum of 4 weeks.

In Switzerland only available from pharmacies abroad.

Germany: Fiblaferon® 0.1 million IU/g, 5x daily.

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  2. Drago, F. and A. Rebora, The New Herpesviruses. Arch Dermatol, 1999. 135(1).
  3. Arvin, A.M., R.J. Whitley, and K.M. Gutierrez, Herpes Simplex Virus Infections, in Infectious Diseases of the Fetus and Newborn Infant. 2006, Elsevier BV. p. 845-865.