Cystic basal cell carcinoma
Last Updated: 2020-08-17
ICD11: -
Last Updated: 2020-08-17
Author(s): Anzengruber F., Navarini A.
ICD11: -
Cystic basalioma.
Special histological form of basal cell carcinoma.
Predilection sites: eyelids, cheeks, nose, ears.
Skin-coloured, soft-palpable, glassy papules with telangiectasia, usually measuring only 0.5 cm in diameter.
Cystic and adenoidal structures, basaloidal tumor cell strands.
1st choice therapy by Lebwohl |
Level of evidence |
Curettage and electrodesiccation |
B |
Surgical excision |
B |
Moh's surgery (micrographically controlled) |
B |
Cryotherapy | B |
2nd choice therapy by Lebwohl |
|
Radiotherapy |
B |
3rd choice theraoy by Lebwohl |
|
Interferon intralesional |
B |
Retinoids |
D |
Imiquimod |
A |
Photodynamic therapy |
A |
5-fluorouracil |
A |
CO² laser |
D |
PEG interleukin 2 |
D |
NSAIDs |
D |
Ingenol butate |
D |
Vismodegib |
A |
Intralesional Interleukin application |
D |
Systemic chemotherapy |
D |
Surgical therapy
The gold standard of basal cell carcinoma therapy
Especially infiltrative growing and sclerodermiform basal cell carcinomas should be excised surgically
In case of incomplete resection, a post-excision should be performed, except in well-founded cases.
BCC Ø < 2 cm |
Infiltrative BCC |
||||
Safety margin |
3 mm |
4-5 mm |
3 mm |
5 mm |
13-15 mm |
Likelihood that tumor residue remains |
15% |
5% |
34% |
18% |
5% |
Source: Hauschild, A. (2016). Langfassung der Leitlinie "Basalzellkarzinom der Haut". Awmf.org. Retrieved 30 May 2016, from http://www.awmf.org/leitlinien/detail/ll/032-021.html
Curettage with/without electrodesiccation
Cryotherapy
Laser treatment
Photodynamic therapy
Imiquimod cream 5% daily 5x/week for a total of 6 weeks.
5-fluorouracil (5% in cream), topically applied daily for four to six weeks
Radiotherapy
Hedgehog Inhibitor (Vismodegib)
Experimental Therapies
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