Dermatofibroma

Last Updated: 2020-08-07

Author(s): Anzengruber, Navarini

Histiocytoma, dermatofibroma lenticulare, fibroma en pastille, hard fibroma, Subepidermal nodular fibrosis, Sclerosing angioma

Dermatofibroma is a benign dermal and superficial subcutaneous proliferation. It is made up of  oval cells which resemble histiocytes, and spindle‐shaped cells resembling fibroblasts and myofibroblasts.

More common in women in young adulthood.

  • Trigger:
    • Ictus reaction
    • Folliculitis
    • Ruptured cyst
    • Microtrauma

This is followed by an inflammatory reaction of the connective tissue.

Mostly appears on the lower extremity as a red/brown, sharply defined, lenticular nodule is visible.

If the skin lesion is fixed between thumb and index finger, the nodule sinks (Fitzpatrick sign).

In the case of unusually large dermatofibromas (> 5 cm diameter) one speaks of giant dermatofibromas.

  • Clinical features
  • Biopsy if uncertain.

Taking medication.

Usually no treatment is necessary. However, cellular, atypical and aneurysmal variants should be completely removed conservatively.

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