Endemic spotted fever
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
Flea spotted fever, murine spotted fever, rat spotted fever.
Notifiable rickettsial disease, which is similar to epidemic typhus but milder.
- Pathogen: Rickettsia typhi
- Transmission is by the rat flea
- Like epidemic typhus, but much milder
- Unspecific early stage (cephalgia, exhaustion)
- In the course: Fever, somnolence
- 3-6 days after onset of fever Appearance of roseolae with partly punctate haemorrhages on the trunk, which spread centrifugally. Palmoplantar involvement
- Muscle twitching, tenderness of peripheral nerves, motor restlessness
- Bronchitis, conjunctivitis, splenomegaly
- Mostly lice can be detected (pediculosis corporis)
- Facies typhosa: Livid-reddish face
- Lice infestation
- BB (mild leukocytosis or leukopenia, eosinophilia, thrombocytopenia), liver and kidney values (elevated transaminases in up to 90%), electrolytes (hyponatremia)
- Lumbar puncture in case of suspected meningitis
- From the 2nd week of illness Weil-Felix reaction (agglutination test)
- From the 3rd week of illness, complement fixation reaction
- From the 3rd week of illness indirect immunofluorescence test
- De Sousa, R., et al., Molecular detection of Rickettsia felis, Rickettsia typhi and two genotypes closely related to Bartonella elizabethae. Am J Trop Med Hyg, 2006. 75(4): p. 727-31.
- McLeod, M.P., et al., Complete genome sequence of Rickettsia typhi and comparison with sequences of other rickettsiae. J Bacteriol, 2004. 186(17): p. 5842-55.
- Nogueras, M.M., et al., Serological evidence of infection with Rickettsia typhi and Rickettsia felis among the human population of Catalonia, in the northeast of Spain. Am J Trop Med Hyg, 2006. 74(1): p. 123-6.