Granuloma inguinale
Last Updated: 2020-08-07
ICD11: 1A91
Last Updated: 2020-08-07
Author(s): Anzengruber F., Navarini A.
ICD11: 1A91
McLeod 1882.
Donovanosis, Granuloma venereum.
Venereal disease caused by the intracellular Calymmatobacterium granulomatis (Donovania granulomatis, Klebsiella granulomatis).
The pathogen is Klebsiella granulomatis, formerly known as Calymmatobacterium granulomatosis or Donovania granulomatosis.
Pathogen intracellularly in macrophages. In Giemsa staining or silver plating, bipolar cocoid, intracytoplasmic inclusion corpuscles (Donovan corpuscles) can be formed from clusters of pathogens.
If left untreated, in 10% of cases a peripheral expansion occurs, which can assume monstrous proportions. Obstruction of the lymphatic vessels can lead to elephantiasis of the penis, scrotum and labia.
In the course of the disease, a spinocellular carcinoma may develop.
Partner co-treatment!
Surgical removal of the exophytic skin alterations.
Topical therapy
Systemic therapy
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