Keratosis palmoplantaris diffuse with mutations in keratin 1

Last Updated: 2023-07-07

Author(s): Anzengruber F., Navarini A.

ICD11: -

  • Palmoplantar keratoses

  • Keratosis palmoplantaris diffusa transgrediens et progrediens Greither
  • Non-epidermolytic PPK
  • Keratosis extremitatum hereditaria transgreden et progrediens.

Palmoplantar keratosis with mutation in the keratin 1 gene.

Autosomal dominant mutation of the keratin 1 gene.

Initiation in the first years of life.

Diffuse palmoplantar keratosis with transgression to the dorsum of the hands and feet.

Hyperkeratotic plaques on knees, elbows and other localisations.

 

Anamnesis

Clinical

Genetic examination, regarding a mutation in keratin 1.

Familial occurrence?

Initiation of hyperkeratosis.

From the 4th decade of life, the disease usually comes to a standstill.

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  2. Tay YK. What syndrome is this? Greither syndrome. Pediatr Dermatol. 2003 May-Jun;20(3):272-5. 
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