Keratosis palmoplantaris with mutations in TOC

Last Updated: 2023-07-07

Author(s): Anzengruber F., Navarini A.

ICD11: -

Howel-Evans 1958

Howel-Evans syndrome.

Keratoderma with oesophageal carcinoma.

Palmoplantar keratosis, which is associated with the development of oesophageal carcinoma.

Autosomal dominant inheritance.

Mutation in the TOC region (tylosis oesophageal cancer).

Palmoplantar hyperkeratosis.

Keratosis follicularis.

Development of oesophageal carcinoma.



Genetic examination

Gastroenterology consult.

Familial occurrence of palmoplantar hyperkeratosis and oesophageal carcinoma?

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  2. Kallini JR, Sadeghani K, Khachemoune A. Paraneoplastic palmoplantar keratoderma secondary to metastatic uterine adenocarcinoma. Cutis. 2017 Mar;99(3):E32-E35.