Keratosis palmplantaris with mutations in TOC

Last Updated: 2019-08-26

Author(s): Anzengruber F., Navarini A.

ICD11: -

Howel-Evans 1958

Howel Evans syndrome.

Keratodermia with esophageal carcinoma.

Palmoplantar keratosis associated with the development of esophageal carcinoma.

Autosomal dominant inheritance.

Mutation in the TOC region (tylosis oesophageal cancer).

Palmoplantare hyperkeratosis.

Keratosis follicularis.

Development of esophageal carcinoma.



Genetic investigation 

Gastroenterological Consil 

Familial occurrence of palmoplantar hyperkeratosis and esophageal carcinoma?

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  2. Kallini JR, Sadeghani K, Khachemoune A. Paraneoplastic palmoplantar keratoderma secondary to metastatic uterine adenocarcinoma. Cutis. 2017 Mar;99(3):E32-E35.