Maculopapular drug reaction
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: EH60
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: EH60
Late-type drug reaction.
One of the most common forms of cutaneous adverse drug reactions.
Common triggers
Appearance of the first skin changes:
Almost obligatory is maculopapular drug exanthema after infectious mononucleosis and ingestion of penicillin antibiotics
Erythematous, maculopapular, sometimes rubeoliform, in some cases morbilliform or scarlatiniform, usually symmetrical efflorescences. In some cases, gyrated or reticular exanthema is also seen. In rare cases, some drug exanthemas may be unilateral (e.g.: in hemiplegia) and localised (exclusively) in the body folds.
Optional accompanying symptoms
Systemic signs
Caution in case of indications/signs of severe drug reactions: e.g. pustular, vesicular blistering, painfulness of skin lesions, involvement of mucous membranes, skin fragility, facial oedema, blood eosinophilia.
Beginning mostly on the trunk, in the course spreading to include the extremities, especially the extensor sides. Usually the face and body folds are left out.
Systemic therapy
After > 6 weeks:
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