Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
Röschenflechte, Gibert's disease.
Self-limiting, exanthematous, inflammatory skin disease.
- Age peak: 10-35 years
- Women > men
- Occurring in all ethnicities
- Prevalent mainly in spring and autumn
- The cause is not yet known
- Possible triggers:
- Viral infections (HHV-6, HHV-7, H1N1, EBV, CMV)
- Increases in tissue-derived interleukin-17 (IL-17) and -22, interferon-γ, vascular endothelium growth factor (VEGF) and CXCL10 (IP-10) have been shown
- ↓ general condition, nausea, (sub-)febrile temperatures, cephalgia
- Sharply demarcated, erythematous, oval plaques with collerett-like scaling. A tache mère (sometimes called plaque mère, herald patch or primary medallion) manifests first. This is usually located on the trunk and is larger than all the others
- As it progresses, the skin lesions spread along the cleavage lines (Christmas tree pattern)
- The face and distal halves of the extremities are usually left out. The oral mucosa (enanthema) is involved only in exceptional cases
- Special forms:
- Pityriasis rosea inversa: It mainly affects the axillae and the groin region. An inverse form may be seen in children or African-Americans
- The skin lesions may also be atypical: urticarial, haemorrhagic, follicular bound, vesicular, psoriasiform and circine
- Anamnesis (previous infections?)
- Clinical image (search for plaque mère)
Discreet focal spongiosis and parakeratosis are visible in the epidermis. Erythrocyte extravasations are typical but rare. A perivascular lymphocytic infiltrate is seen in the dermis.
- Healing after 3-8 weeks
- Disease can lead to abortion or premature birth in pregnant women (up to 15 weeks gestation)
- Pityriasis rosea, in SpringerReference. Springer Science + Business Media.
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