Primary cutaneous intravascular large B-cell lymphoma

Pfleger und Tappeiner 1959.

Angioendotheliomatosis proliferans systemisata.

Rare B-cell lymphoma. 

• Men = Women
• Frequency peak ≥ 60 years old

Due to intravascular tumor cell infiltrates, an occlusion of smaller vessels occurs.

• In the area of the legs and the lower abdomen there are few characteristic reddish, infiltrated, sometimes slightly bluish, sometimes ulcerated nodules and plaques.

• Reduced general condition, fever, B symptoms, neurological deficits (dementia, visual and speech disorders). 

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3. Tanaka, Y., et al., Intravascular large B-cell lymphoma secondary to lymphoplasmacytic lymphoma: a case report and review of literature with clonality analysis. Int J Clin Exp Pathol, 2015. 8(3): p. 3339-43.
4. Maekawa, T., et al., Random skin biopsy of patients with intravascular large B-cell lymphoma associated with thrombocytopenia and coagulation abnormalities: proposal of a modified biopsy method. J Dermatol, 2015. 42(3): p. 318-21.
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