Last Updated: 2023-07-07

Author(s): Anzengruber F., Navarini A.

ICD11: 2F22

Syringocystadenoma described by Neumann, syringoma by Fiocco

Syringocystadenoma, hidradenoma eruptivum

Adult age

Darier's hidradenoma eruptivum, and the more common syringoma of the eyelids


Unclear, possibly embryonic tissue.

Multiple, oval, pale pink or yellowish, non-scaling, pinhead to pea-sized papules. The long axis of the oval follows the skin folds. Elevated above the skin surface, palpable.




Eye lids, eruptive syringomas but also on the neck, shoulders, chest.

Eruptive syringomas occur during childhood, periorbital slowly in adulthood. Association with trisomy 21, anti-epilepsy medication, hyperthyroidism, diabetes mellitus. Köbnerisation by inflammation or hair waxing has also been described.

Multiple, small epithelial cell collections with central ducts surrounded by a cuboidal cell layer. A comma-like shape is quite typical and often visible, well demarcated from the fibrotic stroma.

Not possible.

No spontaneous response.

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