Typhoid fever

Last Updated: 2019-08-26

Author(s): Anzengruber F., Navarini A.

ICD11: -

Notifiable, potentially fatal infection with Salmonella typhi.

Approx. 500,000 deaths / year.

  • Causative organism 
    • Salmonella typhi.
  • Transmittance
    • Contamination of food by faeces.

  • The reservoir of the pathogen is man. Asymptomatic excretion is also possible.

  • Fever, reduced general condition, constipation and cephalgias.

  • Erythematous maculae (roseoles) can develop abdominal and transform into papules in the course.

  • Healing can take place with postinflammatory hyperpigmentation.

  • Clinic 

  • Stool sample for pathogen detection.

  • Serological antibody detection.

  • If necessary, dermatopathological protection.

Extended capillaries correlate with roseoles.

  • Ciprofloxacin p.o. 500 mg 2x daily for 14 days.

  • The detection of the pathogen must be reported.

  1. Chapman AS, Swerdlow DL, Dato VM, Anderson AD, Moodie CE, Marriott C et al. Cluster of Sylvatic Epidemic Typhus Cases Associated with Flying Squirrels, 2004–2006. Emerg Infect Dis 2009;15:1005-11.
  2. Dumler JS. Clinical and Laboratory Features of Murine Typhus in South Texas, 1980 Through 1987. JAMA 1991;266:1365.
  3. Kim I-S , Walker DH. Scrub Typhus. Tropical Infectious Diseases: Principles, Pathogens and Practice: Elsevier BV; 2011. p. 334-8.
  4. Raoult D, Ndihokubwayo JB, Tissot-Dupont H, Roux V, Faugere B, Abegbinni R et al. Outbreak of epidemic typhus associated with trench fever in Burundi. The Lancet 1998;352:353-8.
  5. Watt G, Chouriyagune C, Ruangweerayud R, Watcharapichat P, Phulsuksombati D, Jongsakul K et al. Scrub typhus infections poorly responsive to antibiotics in northern Thailand. The Lancet 1996;348:86-9.
  6. Watt G , Parola P. Scrub typhus and tropical rickettsioses. Current Opinion in Infectious Diseases 2003;16:429-36.