Blood count, (if leukocytes <3x103/μl: differential blood count), kidney values, liver values, Hep B/ C/ HIV serology, TPMT determination prior to start of therapy
1 mg/kg bw/d, within 3 - 4 weeks gradual increase to 1.5- 3 mg/kg bw/d maintenance dose
At the earliest 4 - 6 weeks, usually after 2 - 3 months
Kidney/ liver disease (dose adjustment), with simultaneous administration of allopurinol: reduction of azathioprine to 1/4 of the dose, combination with succinylcholine, tubocurarin, cytostatics, no live vaccines, with SS: max 2 mg/kg bw/d, annual flu and pneumococcal vaccination recommended, with HIV infection: individual risk assessment, TPMT-development (myelotoxicity). Cutaneous carcinogenesis
Bone marrow diseases (cytopenia), chronic Hep B (pos HbsAG), breastfeeding; SS (relative contraindication) and breastfeeding period
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