2-3 mg /kg bw /d initial, with inefficiency increase by 0.5-1 mg /kg bw /d, maximum 5 mg/kg bw/d
Nephrotoxic drugs, liver diseases, other immunosuppressants, previous phtotherapy, live vaccines. Annual flu and pneumococcal vaccination recommended, individual risk assessment for HIV infection. Combination with statins: Danger of myopathies CAVE: Effect of pro- gesteron-containing anti-contraceptives can be reduced.
Renal dysfunction, uncontrolled arterial hypertension, severe infections, malignancies, except excised epithelial skin tumors, lactation, chronic hypertension, chronic skin cancer. Hep B (pos HbsAG). Simultaneous PUVA therapy
Side effects at 3-5 mg/kg are usually limited to a few weeks to months. For inflammatory skin diseases no longer than 12 months due to calcineurin inhibitor-induced nephropathy and increased carcinogenesis.
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