Dapsone (previously determine G6PDH activity)


Differential blood count, reticulocytes, liver values, kidney values, glucose 6-phosphate dehydrogenase activity, Met-Hb, SS test recommended


3d 1x25 mg/d, 3d 2x25 mg/d, 3d 3x25 mg/d, 3d 2x50 mg/d, possibly up to 150 mg/d, combination with Vit. E, approx. 600 - 900 E/d -> less MetHb formation

Weeks to days, depending on the disease

G6PDH-De zienz -> Hemolysis

Sulphone allergy, cardiac insuficiency, pulmonary insuficiency, anemia, Hb < 11 g/dL (relative KI), Hb < 9 g/dL (absolute KI), pregnancy/breastfeeding time

Noxae, vomiting -> dose reduction, exertion dyspnoea -> dose reduction, anemia, methemoglobinemia > 15 % -> dose reduction, possible termination, agranulocytosis -> dose reduction, possible termination, eosinophilia, toxic hepatitis, dapson hypersensitivity syn- drome -> dose reduction, possible termination

Not limited