Fumaric acid ester

Fumaric acid ester

blood count (BB), liver values, kidney values, U status: Application for cost assumption necessary


30 mg p.o., weekly increase by 30 - 120mg to 720mg

6 - 8 weeks

MTX, retinoids, ciclosporin, psoralenes, kidney toxin drugs

pregnancy, lactation, renal and gastrointestinal dysfunctions, severe liver dysfunction, malignant diseases, hypersensitivity to fumaric acid esters

Gastrointestinal complaints (~60 % in the first weeks), flush -> intake in the evening with milk. Lym- phopenie -> under 500/μl dose reduction or stop. Eosinophilia -> always temporary. Abdominal cramps, flatulence

Not limited