Creatinine Cl < 25 ml/min, max 2 g CellCept/d resp. 1.44 g Myfortic/d, no live vaccines, annual flu and pneumococcus vaccination recommended, in HIV infection individual risk assessment, antacids and cholestyramine decrease enteral absorption, Probenecid decreases renal excretion
Bone marrow diseases (cytopenia), chronic Hepatitis B (pos. HbsAG); SS and breastfeeding period
Gastrointestinal complaints -> dose reduction or division into 4 - 6 individual doses/d, infections -> interruption, possible termination. Neutropenia < 1.3x103/μl -> Interruption. Thrombopenia < 80 - 100x103/μl -> Interruption, possibly abortion. In case of other side effects consult specialists. Increased risk of lymphoma and other malignancies, especially of the skin.
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