Sirolimus

Rapamune
"Always with or always without food and 4 h after the Ciclosporin microemulsion; table 0.5 mg not bioequivalent with table 1 mg/2 mg; solution: dilute with min. 60 ml water or orange juice, rinse again with min. 120 ml water or orange juice and drink. >13 y.: initial: 1×6 mg, then 1×tgl. 2 mg; Receipt: individually according to Sirolimus whole blood level (initial therapy with Ciclosporin: 4-12 ng/ml, maintenance therapy without Ciclosporin: 12-20 ng/ml), dose adjustment after discontinuation of Ciclosporin: "K", max. 40 mg daily".
Tbl.
systemic