Meningoenzephalitis herpetica

Selten vorkommende, durch Herpes-Viren ausgelöste Gehirnhautentzündung. Häufigste Virus- Enzephalitis bei Erwachsenen.

V.a. bei Neugeborenen und Kindern.

• Akuter Beginn
• Reduzierter AZ
• Schwindel
• Kopfschmerzen
• Meningismus
• hohes Fieber
• Tinnitus aurium
• Übelkeit, Erbrechen
• Krampfanfälle
• komatöser Bewusstseinszustand

• Klinik
• Virusisolation aus Liquor oder Blut
• Procalcitonin ist nicht erhöht (bakt. Meningitis)

Ggl. neurologische Ausfälle.

1. Kotzbauer, D., et al., Clinical and laboratory characteristics of central nervous system herpes simplex virus infection in neonates and young infants. Pediatr Infect Dis J, 2014. 33(11): p. 1187-9.
2. Kuypers, J., et al., Comparison of the Simplexa HSV1 & 2 Direct kit and laboratory-developed real-time PCR assays for herpes simplex virus detection. J Clin Virol, 2015. 62: p. 103-5.
3. Cunha, B.A. and J. Baron, The pharmacokinetic basis of oral valacyclovir treatment of herpes simplex virus (HSV) or varicella zoster virus (VZV) meningitis, meningoencephalitis or encephalitis in adults. J Chemother, 2015: p. 1973947815Y0000000065.
4. de Almeida, S.M., et al., Reactivation of herpes simplex virus-1 following epilepsy surgery. Epilepsy Behav Case Rep, 2015. 4: p. 76-8.
5. Montano, S.M., et al., Herpes simplex virus encephalitis in Peru: a multicentre prospective study. Epidemiol Infect, 2016: p. 1-6.
6. Zhang, L., J.J. Liu, and M.T. Li, Herpes simplex virus type 1 encephalitis and unusual retinitis in a patient with systemic lupus erythematosus. Lupus, 2013. 22(13): p. 1403-8.
7. Vik-Mo, E.O., et al., Reactivation of occult herpes simplex meningoencephalitis after temporal lobe resection for refractory epilepsy--a case report. Seizure, 2014. 23(4): p. 321-3.
8. Oumerzouk, J., et al., [Kluver-Bucy syndrome complicating herpes meningoencephalitis in a pregnant woman]. Presse Med, 2014. 43(7-8): p. 871-4.
9. Barnes, K.J., et al., Herpes simplex encephalitis in a captive black howler monkey (Alouatta caraya). J Vet Diagn Invest, 2016. 28(1): p. 76-8.
10. Pollak, L., et al., Varicella zoster vs. herpes simplex meningoencephalitis in the PCR era. A single center study. J Neurol Sci, 2012. 314(1-2): p. 29-36.
11. Abe, M., et al., Varicella Zoster Virus Meningoencephalitis Presenting with Elsberg Syndrome without a Rash in an Immunocompetent Patient. Intern Med, 2015. 54(16): p. 2065-7.