Actinic Prurigo

Last Updated: 2019-08-27

Author(s): Anzengruber F., Navarini A.

ICD11: -

Lopez-Gonzáles 1961

Hereditary polymorphic light dermatosis
Familiar actinic prurigo


Mostly occurring in childhood.
Family variants can be seen in the indigenous population of America.

This is caused by UV-B and UV-A radiation. The further pathomechanism is unknown. Some authors postulate a UV-induced hypersensitivity reaction of the delayed type.
Usually there is an association to an atopic diathesis.

Initially urticarial skin lesions in areas exposed to light, which develop into lichenified plaques and prurigo nodules in the course of time. Cheilitis is often also visible.

Medical history
Photo Provocation Test (LINK)
Biopsy, if necessary


Acanthosis, spongiosis, dermal infiltration of lymphocytes and histiocytes (partly also eosinophils), especially perivascular.


UV protection (incl. sunglasses)- incl. UVA!
Light hardening (LINK)

Spontaneous remission during puberty.

  1. Plaza JA, Toussaint S, Prieto VG, Mercadillo P, Diez de Medina JC, Lourenco S, Batdorf B, Sangueza M. Actinic Prurigo Cheilitis: A Clinicopathologic Review of 75 Cases. Am J Dermatopathol. 2016 Jun;38(6):418-22.
  2. Rodríguez-Carreón AA, Rodríguez-Lobato E, Rodríguez-Gutiérrez G, Cuevas-González JC, Mancheno-Valencia A, Solís-Arias MP, Vega-Memije ME, Hojyo-Tomoka MT, Domínguez-Soto L. Actinic Prurigo. Skinmed. 2015 Aug 1;13(4):287-95.