Actinic prurigo

Last Updated: 2023-07-07

Author(s): Anzengruber F., Navarini A.

ICD11: EJ30.Y

Lopez-Gonzáles 1961

Hereditary polymorphous light dermatosis

Familial actinic prurigo



Mostly occurring in childhood.

Familial variants are seen in the indigenous population of the Americas.

The main cause is UV-B and also UV-A radiation. The further pathomechanism is unknown. Some authors postulate a UV-induced hypersensitivity reaction of the delayed type

Mostly there is an association with an atopic diathesis.

Initially in areas exposed to light, urticarial skin lesions develop into lichenified plaques and prurigo nodules. Cheilitis is often visible as well.



Photoprovocation test

If necessary, biopsy


Acanthosis, sponiogsis, dermal infiltration of lymphocytes and histiocytes (sometimes also eosinophils), especially perivascularly.


UV protection (incl. sunglasses)- incl. UVA!

Light hardening

Spontaneous remission at puberty.

  1. Plaza JA, Toussaint S, Prieto VG, Mercadillo P, Diez de Medina JC, Lourenco S, Batdorf B, Sangueza M. Actinic Prurigo Cheilitis: A Clinicopathologic Review of 75 Cases. Am J Dermatopathol. 2016 Jun;38(6):418-22.
  2. Rodríguez-Carreón AA, Rodríguez-Lobato E, Rodríguez-Gutiérrez G, Cuevas-González JC, Mancheno-Valencia A, Solís-Arias MP, Vega-Memije ME, Hojyo-Tomoka MT, Domínguez-Soto L. Actinic Prurigo. Skinmed. 2015 Aug 1;13(4):287-95.