Albright syndrome

Last Updated: 2023-07-07

Author(s): Anzengruber F., Navarini A.

ICD11: -

McCune 1936

Albright 1937

Polyostotic fibrous dysplasia

Genodermatosis, which is defined by the triad: café au lait spots, pubertas praecox and fibrous dysplasia.

Postzygotic mutation of the GNAS11 gene.

Sharply defined, irregular (Coast of Maine), brownish macules, following Blaschko lines.

Pubertas praecox.

Fibrous dysplasia (predisposition to fractures)

Frequent endocrinological abnormalities

Anamnesis (e.g. bone fractures)


Genetic analysis.

Endocrinological consultation.

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  2. Lietman SA, Levine MA. Fibrous dysplasia. Pediatr Endocrinol Rev. 2013 Jun;10 Suppl 2:389-96.
  3. Martin-Carreras T, Sanchez E, Bancroft LW. Polyostotic fibrous dysplasia. Orthopedics. 2014 Nov;37(11):722-82.