Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
- Odriozola 1895
- Barton 1909
- Verruga peruana
- Carrión fever
- Oroya fever
Infectious disease which, in addition to cutaneous manifestation, also leads to sepsis.
- occurrence only in the high mountain valleys (600-3000m) of Peru, Ecuador and southwest Colombia
- Approximately 5% of the population of the endemic area is expected to be asymptomatic carriers
- Pathogen: Bartonella bacilliformis
- Transmission: sand flies of Lutzomyia spp., especially Lutzomia verrucarum
- Transmission occurs during the act of sucking and after blood transfusions
- Incubation period: weeks - months
- Bartonella bacilliformis causes both dermal nodules (verruga peruana) and sepsis (Oroya fever)
- The cutaneous manifestation includes pedunculated, verruciform, grouped and eroded papules and nodules. In particular, the face, extremities, but also mucous membranes are affected. Petechial exanthema
- Sepsis, reduced general condition, fever, anaemia, hepatosplenomegaly, lymphadenopathy
- A secondary infection with salmonella may occur
- Travel history
- Detection of pathogens by blood culture or biopsy
- Similar to bacillary angiomatosis
- Bacterial detection is achieved by Warthin-Starry staining
- Letality: 10-90%
- Survivors experience spontaneous recovery, often after years
- Angelakis E , Raoult D. Pathogenicity and treatment of Bartonella infections. Int J Antimicrob Agents 2014;44:16-25.
- Breitschwerdt EB. Bartonellosis: one health perspectives for an emerging infectious disease. ILAR J 2014;55:46-58.
- Bai Y, Malania L, Alvarez Castillo D, Moran D, Boonmar S, Chanlun A et al. Global distribution of Bartonella infections in domestic bovine and characterization of Bartonella bovis strains using multi-locus sequence typing. PLoS One 2013;8:e80894.
- Prutsky G, Domecq JP, Mori L, Bebko S, Matzumura M, Sabouni A et al. Treatment outcomes of human bartonellosis: a systematic review and meta-analysis. Int J Infect Dis 2013;17:e811-9.
- Edouard S, Nabet C, Lepidi H, Fournier PE , Raoult D. Bartonella, a common cause of endocarditis: a report on 106 cases and review. J Clin Microbiol 2015;53:824-9.
- Fleischman DA, Chomel BB, Kasten RW, Andre MR, Goncalves LR , Machado RZ. Bartonella clarridgeiae and Bartonella vinsonii subsp. berkhoffii exposure in captive wild canids in Brazil. Epidemiol Infect 2015;143:573-7.