Gianotti Crosti syndrome
Last Updated: 2021-10-15
ICD11: -
Last Updated: 2021-10-15
Author(s): Anzengruber F., Navarini A.
ICD11: -
Gianotti 1955, Crosti und Gianotti 1956.
Acrodermatitis papulosa eruptiva infantilis, Acrodermatitis papulosa eruptiva infantilis, Akrodermatitis papulose eruptive infantilis, infantile papulöse Akrodermatitis, infantiles akrolokalisiertes papulovesikulöses Syndrom, GCS.
Minor childhood contagious disease.
A viral infection (HBV, EBV, coxsackie virus, cytomegaloviruses, adenoviruses, enteroviruses, HHV-6, HHV-7, HIV, RSV, parainfluenza virus, parvovirus B19) or a vaccination (sometimes up to 6 weeks ago) can be the trigger. In special cases, irritation of Mollusca contagiosa can lead to a generalized Gianotti-Crosti syndrome.
In the past, hepatitis was thought to be the cause, which was not confirmed.
The prodromi are uncharacteristic. General symptoms: Elevated (subfebrile) temperature, lymphadenopathy, dyspepsia, rhinopharyngitis, bronchitis, tonsillitis, occasional hepatomegaly, reactive polylymphadenitis. fatigue, headaches.
Laboratory: Blood count (leukocytosis, lymphocytosis and monocytosis), BSG, CRP, HBs-AG, HBe-AG, liver values, bilirubin, protein electrophoresis (reproduction of β-, β- and later α-globulins).
Acra (cheeks, extremity sides and buttocks).
Spongiosis, hyper- and parakeratosis, secondary acanthosis and exocytosis are visible in the epidermis.
The papillary stratum and the reticular stratum show subacute vasculitis with perivascular edema and lymphohistiocytic infiltration.
Healing after 2-8 weeks.
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