Gianotti Crosti syndrome

Last Updated: 2021-10-15

Author(s): Anzengruber, Navarini

Gianotti 1955, Crosti und Gianotti 1956.

Acrodermatitis papulosa eruptiva infantilis, Acrodermatitis papulosa eruptiva infantilis, Akrodermatitis papulose eruptive infantilis, infantile papulöse Akrodermatitis, infantiles akrolokalisiertes papulovesikulöses Syndrom, GCS.

Minor childhood contagious disease.

  • Boys are more frequently affected.
  • Mostly occurring at the age of 2-6 years.
  • Seasonal accumulation in spring and autumn.
  • Incubation period: 1-6 weeks.
  • A viral infection (HBV, EBV, coxsackie virus, cytomegaloviruses, adenoviruses, enteroviruses, HHV-6, HHV-7, HIV, RSV, parainfluenza virus, parvovirus B19) or a vaccination (sometimes up to 6 weeks ago) can be the trigger. In special cases, irritation of Mollusca contagiosa can lead to a generalized Gianotti-Crosti syndrome.

In the past, hepatitis was thought to be the cause, which was not confirmed.

  • After 3-4 days, erythematous, succulent, confluent lichenoid papules.
  • The prodromi are uncharacteristic. General symptoms: Elevated (subfebrile) temperature, lymphadenopathy, dyspepsia, rhinopharyngitis, bronchitis, tonsillitis, occasional hepatomegaly, reactive polylymphadenitis. fatigue, headaches.

  • Laboratory: Blood count (leukocytosis, lymphocytosis and monocytosis), BSG, CRP, HBs-AG, HBe-AG, liver values, bilirubin, protein electrophoresis (reproduction of β-, β- and later α-globulins).

Acra (cheeks, extremity sides and buttocks).

  • Spongiosis, hyper- and parakeratosis, secondary acanthosis and exocytosis are visible in the epidermis.

  • The papillary stratum and the reticular stratum show subacute vasculitis with perivascular edema and lymphohistiocytic infiltration.

Healing after 2-8 weeks.

  • Lotio Alba
  • Lotio Alba
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