Microsporia

• Gruby, 1841
• Sabouraud, 1892

Gruby's disease, Porrigo decalvans.

Special form of tinea capitis.

Endemics can occur especially in kindergartens and schools.

• Pathogen: M. canis, gypseum, audouinii, ferrugineum (zoophilia)
• Transmission occurs via a contaminated animal (usually cat or dog). The infection is highly contagious and can spread to the entire integument.

Erythematous, slow-growing, scaly plaques, often raised at the edges.

• Clinic
• Detection of pathogens (epilation of hair or recovery of dandruff: then native preparation and culture; biopsy)
• Wood light (greenish fluorescence)

• All animals that have been in contact should be examined and treated.
• Examination of other persons in the household
• Therapy should be given with both topical and systemic antifungal agents!

Topical therapy

• Clotrimazole cream
• Terbinafine cream (1%)
• Ketoconazole cream (2%)
• Amorolfin cream (0.25%)
• Griseofulvin cream: not on the market in Switzerland
• Bifonazole cream: not on sale in Switzerland)
• Econazole cream (1%)
• Ciclopirox cream (or lsg.)

• Shampoo containing ketoconazole: leave on for 5- 10 minutes. Repeat on the 2 following days
• Ciclopirox-containing shampoo: leave on for 5- 10 minutes. Repeat on the 2 following days
• Pregnancy: Only nystatin is allowed

Systemic therapy

• Griseofulvin p.o. 500-1000 mg daily (not commercially available in Switzerland)
• Alternative: Terbinafine p.o. 250 mg 1x tgl.
• Alternative: Itraconazole p.o. 200 mg 1x tgl.
for 7 days
• Alternative: Griseofulvin p.o. 500 mg 2x tgl. (not commercially available in Switzerland)

1. Ginarte, et al., Case Reports. Pityriasis amiantacea as manifestation of tinea capitis due to Microsporum canis. Mycoses, 2000. 43(1-2): p. 93-96.
2. Hamm, et al., Short duration treatment with terbinafine for tinea capitis caused byTrichophytonorMicrosporumspecies. British Journal of Dermatology, 1999. 140(3): p. 480-482.
3. Ishizaki, S., et al., Tinea Faciei by Microsporum gypseum Mimicking Allergic Reaction following Cosmetic Tattooing of the Eyebrows. Medical Mycology Journal, 2012. 53(4): p. 263-266.
4. Zink, A., et al., Outbreak of Microsporum audouinii in Munich--the return of infectious fungi in Germany. Mycoses, 2014. 57(12): p. 765-70.
5. Treat, J. (2016). Tinea capitis. Uptodate.com. Retrieved 30 May 2016, from ttp://www.uptodate.com/contents/tinea-capitis?source=machineLearning&search=microsporum&selectedTitle=2~18&sectionRank=1&anchor=H949998314#H949998314