Last Updated: 2019-08-27

Author(s): Anzengruber F., Navarini A.

ICD11: -

  • Kaposi und Hebra 1870.

Disease caused by Klebsiella rhinoscleromatis; an immobile, gram-negative rod.

Today endemic especially in young (20-35th year) patients in Asia, Africa and South America.

  • Pathogen: Klebsiella (pneumoniae) rhinoscleromatis
  • Transmission: Human to human by means of droplet infection.
  • A trigger for the infection might be lack of hygiene. The Klebsiellae phagocytized by the immune system cannot be killed, whereby the granulomatous defence reaction destroys the infected tissue.

  • Rhinitis, fetal nasal secretion with otherwise dry mucous membrane.
  • This is followed by crust formation with inflammatory, hard infiltrates (nose, upper lip and throat) and granulation of the upper lip.

  • Clinic.
  • Dermatopathological protection.
  • Detection of pathogens by bacterial culture.
  • Serological determination of Klebsiellen antibodies.
  • Since the pathogen is infectious and pathogenic for mice, an animal experiment is described.
  • Diagnostic guidance through infectiology.

Nose, oral mucosa and upper respiratory tract.

In the middle corium inflammation with plasma cells, Mikulicz cells and Russell bodies.

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