Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
- Kaposi and Hebra, 1870
Disease caused by Klebsiella rhinoscleromatis, an immobile gram-negative rod.
Today endemic especially in young (20-35 yrs) patients in Asia, Africa and South America.
- Pathogen: Klebsiella (pneumoniae) rhinoscleromatis
- Transmission: human to human via droplet infection
- One trigger for infection is likely to be poor hygiene. The braniae phagocytosed by the immune system cannot be killed, resulting in destruction of the infected tissue due to the granulomatous defence reaction
- Rhinitis, foetid nasal secretion in otherwise dry mucous membrane
- Followed by crusting with inflammatory hard infiltrates (nose, upper lip and throat) and granulations on the upper lip
- Dermatopathological confirmation
- Detection of pathogens by means of bacterial culture
- Serological determination of klebsial antibodies
- Because the pathogen is contagious and pathogenic to mice, an animal test is described, but we do not consider this practical
Nose, oral mucosa and upper respiratory tract.
In the middle corium, inflammation with plasma cells, Mikulicz cells and Russell bodies.
- Andraca R, Edson RS , Kern EB. Rhinoscleroma: A Growing Concern in the United States? Mayo Clinic Experience. Mayo Clinic Proceedings 1993;68:1151-7.
- Bailhache A, Dehesdin D, Francois A, Marie JP , Choussy O. Rhinoscleroma of the sinuses. Rhinology 2008;46:338-41.
- Lenis A, Ruff T, Diaz JA , Ghandour EG. Rhinoscleroma. South Med J 1988;81:1580-2.
- Claveau AM. [Scleroma and rhinoscleroma]. Med Trop (Mars) 1992;52:291-7.
- Tapia A. Rhinoscleroma: a naso-oral dermatosis. Cutis 1987;40:101-3.