Sporotrichosis
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: 1F2J.Z
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: 1F2J.Z
De Beurmann-Gougerot's disease.
Fungal infection of the cutis and subcutis caused by Sporotrix schenckii.
Therapy of 1st choice after Lebwohl | |
Itraconazole | A |
Terbinafine | A |
Potassium iodide | B |
Amphotericin B (in the disseminated form) | E |
Therapy of the 2nd choice after Lebwohl | |
Fluconazole | B |
Heat therapy | D |
Cryotherapy | D |
Topical therapy
Systhemotherapy
form | Therapy of 1st choice | Therapy of 2nd choice | Comment |
Fixed cutaneous form/ Lymphocutaneous form |
Itraconazole (e.g. Sporanox®) p.o. 200 mg 1x tgl. |
Itraconazole (e.g. Sporanox®) p.o. 200 mg 2x tgl. Terbinafine (Lamisil®, Myconormin®) p.o.500 mg 2x tgl. Potassium iodide p.o. 0.5-1.0 ml 3x tgl (increase to 6 ml 3x tgl if necessary). ↑ edible if given with milk. Local hyperthermia |
Therapy should be given for 2-4 weeks after initial symptom relief. |
Disseminated cutaneous form |
Amphotericin B (lipid formulations) i.v. 3-5 mg/kg bw/d, then Itraconazole (e.g. Sporanox®) p.o. 200 mg 1x daily |
Amphotericin B i.v. 0.7 -1.0 mg/kg bw/d, then itraconazole (e.g. Sporanox®) p.o. 200 mg 2x tgl. | Minimum duration of therapy: 12 months, longer if necessary |
Extracutaneous disseminated form |
Itraconazole (e.g. Sporanox®) p.o. 200 mg 1x daily for 7 days Amphotericin B i.v. 0.7 -1.0 mg/kg bw/d |
Minimum duration of therapy: 12 months, longer if necessary | |
Pregnant |
Amphotericin B i.v. 0.7 -1.0 mg/kg bw/d Itraconazole p.o. 6-10 mg/kg bw/d |
- | If possible, it is advisable to wait with therapy until after birth |
Children |
Itraconazole p.o. 6-10 mg/kg bw/d Amphotericin B i.v. 0.7 mg/kg bw/d |
Potassium iodide p.o. 0.5-1.0 ml 3x tgl (increase to 6 ml 3x tgl if necessary). ↑ edible if given with milk. | In severe forms, therapy with first amphotericin B, then itraconazole recommended. |
Source: Kauffmann, C. (2016). Retrieved 30 May 2016, from http://www.uptodate.com/contents/treatment-of-sporotrichosis?source=search_result&search=sporotrichosis&selectedTitle=2~43
Other therapeutic options
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