Last Updated: 2019-08-27
- Schenck 1898
- Lutz u. Splendore 1907
Rose gardener's disease
Fungal infection of the cutis and subcutis by Sporotrix schenckii.
- Fixed cutaneous shape
- Lymphocutaneous form
- Disseminated cutaneous form
- Extracutaneous disseminated form.
Note: in the disseminated and extracutaneous form, bones, joints, lungs, meninges or other visceral organs are usually affected.
- Occurs worldwide, but is a rare disease in Europe.
- Especially in the tropics and subtropics.
- Mexico: most common, deep fungal infection.
The infection is mainly observed in the rural population.
More common in immunocompromised individuals (alcohol abuse, diabetes mellitus, COPD, HIV/AIDS).
- Pathogen: The dimorphic fungus Sporotrix schenckii (Sporotrichon schenckii).
Incubation period: days months.
The dimorphic soil saprophyte Sporotrix schenckii lives on wood and plants. The pathogen can penetrate through injuries (e.g. during gardening) and reaches the deeper layers of the skin and lymph nodes. Aerogenic inoculation or ingestion usually lead to an extracutaneous manifestation (lung, bone, etc.).
Animals may be affected. A transmission from animal to human as well as a human to human transmission is not possible.
Erythematous-brownish, usually asymptomatic, linearly arranged, discreetly scaly, sometimes verrucous, occasionally ulcerating papules, plaques and nodules.
- Clinic, especially the lymphogenic arrangement of efflorescences is indicative
- Myco. smear
Bakt. smear (e.g. of a secondary impetigation)
Biopsy (both dermatopathological and microbiological processing (e.g. MOTT)) recommended.
- Hands and feet are particularly affected.
- Rarely: Face and trunk.
Recurrences are not uncommon.
Rarely spontaneous healings.
- Galhardo MC, De Oliveira RM, Valle AC, et al. Molecular epidemiology and antifungal susceptibility patterns of Sporothrix schenckii isolates from a cat-transmitted epidemic of sporotrichosis in Rio de Janeiro, Brazil. Med Mycol 2008;46:141-51.
- Marimon R, Serena C, Gene J, Cano J, Guarro J. In vitro antifungal susceptibilities of five species of sporothrix. Antimicrob Agents Chemother 2008;52:732-4.
- Fernandez-Silva F, Capilla J, Mayayo E, Guarro J. Efficacy of posaconazole in murine experimental sporotrichosis. Antimicrob Agents Chemother 2012;56:2273-7.
- Bunce PE, Yang L, Chun S, Zhang SX, Trinkaus MA, Matukas LM. Disseminated sporotrichosis in a patient with hairy cell leukemia treated with amphotericin B and posaconazole. Med Mycol 2012;50:197-201.
- Kauffman CA, Pappas PG, McKinsey DS, et al. Treatment of lymphocutaneous and visceral sporotrichosis with fluconazole. Clin Infect Dis 1996;22:46-50.
- Horsburgh CR, Jr., Cannady PB, Jr., Kirkpatrick CH. Treatment of fungal infections in the bones and joints with ketoconazole. J Infect Dis 1983;147:1064-9.
- Calhoun DL, Waskin H, White MP, et al. Treatment of systemic sporotrichosis with ketoconazole. Rev Infect Dis 1991;13:47-51.
- Kauffman CA. Old and new therapies for sporotrichosis. Clin Infect Dis 1995;21:981-5.
- Hiruma M, Kawada A, Noguchi H, Ishibashi A, Conti Diaz IA. Hyperthermic treatment of sporotrichosis: experimental use of infrared and far infrared rays. Mycoses 1992;35:293-9.
- Kauffman CA. Sporotrichosis. Clin Infect Dis 1999;29:231-6; quiz 7.
- Pluss JL, Opal SM. Pulmonary sporotrichosis: review of treatment and outcome. Medicine (Baltimore) 1986;65:143-53.
- Sharkey-Mathis PK, Kauffman CA, Graybill JR, et al. Treatment of sporotrichosis with itraconazole. NIAID Mycoses Study Group. Am J Med 1993;95:279-85.
- Kauffmann, C. (2016). Retrieved 30 May 2016, from http://www.uptodate.com/contents/treatment-of-sporotrichosis?source=search_result&search=sporotrichose&selectedTitle=2~43
- Lebwohl, Mark. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. Elsevier, 2014. Print.