Mycophenolate mofetil

Commercial name

CellCept®, Mycophenolat® Mofetil Sandoz®, Myfenax®

Before therapy

Blood count, liver values, kidney values, Hep B/ C/ HIV serology

Administration

p.o.

Dosage

Cellcept: 2x 250 - 500 mg/d initial, 2x 500 - 1500 mg/d maintenance dose; Myfortic: 2x 180 - 360 mg/d initial, 2x 360 - 720 mg/d maintenance dose

Median effect of action

2 - 4 months

Be careful

Creatinine Cl < 25 ml/min, max 2 g CellCept/d resp. 1.44 g Myfortic/d, no live vaccines, annual flu and pneumococcus vaccination recommended, in HIV infection individual risk assessment, antacids and cholestyramine decrease enteral absorption, Probenecid decreases renal excretion

Contraindications

Bone marrow diseases (cytopenia), chronic Hepatitis B (pos. HbsAG); SS and breastfeeding period

Anamnesis points, selected side effects and measures

Gastrointestinal complaints -> dose reduction or division into 4 - 6 individual doses/d, infections -> interruption, possible termination. Neutropenia < 1.3x103/μl -> Interruption. Thrombopenia < 80 - 100x103/μl -> Interruption, possibly abortion. In case of other side effects consult specialists. Increased risk of lymphoma and other malignancies, especially of the skin.

Duration of theraphy

Not limited

Format

Tbl.

Application

systemic