Tetracyclines / nicotinamide (= vitamin B3) in combination

Last Updated: 2026-09-21

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Before starting treatment

Complete blood count, liver function tests, kidney function tests.

Format

p.o.

Dosage

Doxycycline 2×100 mg per day and 3×500 mg niacinamide per day (Nicobion®).

Onset of effect

Variable

Monitoring intervals

Complete blood count, liver function tests, kidney function tests periodically; initially every 4 weeks. Transaminases ≥3× upper limit of normal: discontinue treatment.

Contraindications

Tetracycline: Transaminases ≥3× the upper limit of normal. Pregnancy, childhood, retinoids (pseudotumour cerebri).

Caution

Liver insufficiency.

Anamnesis points, selected side effects and measures

Tetracycline: photosensitivity (sunburn, nail involvement (nail detachment)), elevated transaminases, oesophagitis, pseudomembranous colitis.
Nausea, fever, reduced general condition: discontinue treatment.

Duration of therapy

Unlimited