Blastic plasmacytoid dendritic cell neoplasm

Last Updated: 2020-06-11

Author(s): Anzengruber F., Navarini A.

ICD11: 2A60.5

Petrella 1999

Aggressive neoplasia which primarily generalizes at the beginning of the skin and in the course of leukaemia.

  • Rare
  • Frequency peak: 70-80 years

  • Erythematous, generalized plaques and lumps on the trunk and head.
  • Involvement of CNS and bone marrow is typical.

The average survival time is 2 years.

  1. Angelot-Delettre, F., et al., In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to SL-401, an interleukin-3 receptor targeted biologic agent. Haematologica, 2015. 100(2): p. 223-30.
  2. Laribi, K., et al., Blastic Plasmacytoid Dendritic Cell Neoplasm: From Origin of the Cell to Targeted Therapies. Biol Blood Marrow Transplant, 2016.
  3. Kim, J.H., et al., Blastic Plasmacytoid Dendritic Cell Neoplasm: Analysis of Clinicopathological Feature and Treatment Outcome of Seven Cases. Ann Dermatol, 2015. 27(6): p. 727-37.
  4. Facchetti, F., et al., Neoplasms derived from plasmacytoid dendritic cells. Mod Pathol, 2016. 29(2): p. 98-111.