Bowen's disease

Last Updated: 2023-07-07

Author(s): Anzengruber F., Navarini A.

ICD11: 2E64.00

Bowen, 1912

M.Bowen, Mb. Bowen, Dyskeratosis maligna, carcinoma in situ, Bowen`s disease, Carcinoma in situ type Bowen`s disease.

Carcinoma in situ, which originates from the keratinocytes. In the area of the genital mucosa, this is called erythroplasia.

  • Increased risk with age
  • Mostly in patients with fair skin type


  • Cumulative UV radiation
  • Arsenic
  • Human papillomavirus

  • Mostly solitary, rather sharply demarcated, erythematous, centrifugally expanding, eczematoid, scaly plaque
  • In 40% the skin change is solitary, in 60% multicentric
  • Eerosive, leukoplakia-like Bowen's disease may occur in the mucosal region

Transition to spinocellular carcinoma in up to 50% of cases


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  2. Majores M, Bierhoff E. [Actinic keratosis, Bowen's disease, keratoacanthoma and squamous cell carcinoma of the skin]. Pathologe 2015;36:16-29.
  3. Thestrup-Pedersen K, Ravnborg L, Reymann F. Morbus Bowen. A description of the disease in 617 patients. Acta Derm Venereol 1988;68:236-9.
  4. Grussendorf EI, Bar T. Condylomata acuminata associated with morbus Bowen (Carcinoma in situ). A light and electron microscopic study. Dermatologica 1977;155:50-8.
  5. Seyss R, Kopf O. [Roentgenotherapy of morbus Bowen and multiple carcinoids]. Krebsarzt 1952;7:15-8.