Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
- Cook 1897
- Kleinschmidt 1935
- McCallum 1948
- Atypical mycobacteriosis caused by Mycobacterium ulcerans
- Infection with the atypical mycobacterium, Mycobacterium ulcerans, an obligate pathogen
- 3rd most common mycobacteriosis in immunocompetent individuals
- Most common in tropical and subtropical areas
- Pathogen: Mycobacterium ulcerans
- Inoculation period: 2-14 weeks
- The route of infection is not clear. Possibly via contaminated soil, plants, possibly insects or from person to person
- S.c., painless, slightly scaly, centrally draining, partly oedematous nodules appear on legs or trunk, which in the course of time transform into a size-progressive ulcer (up to 15% of the KOF)
- In rare cases, there is involvement of the fascia, muscles and bones
- Bact. smear
Granulomas with Langerhans giant cells, acanthosis, hyperkeratosis.
The occurrence of widespread necrosis and seeding of mycobacteria on the bones are possible. Spontaneous remission with scarring is possible.
- Meyers, W.M. and F. Portaels, Mycobacterium ulcerans Infection (Buruli Ulcer), in Tropical Infectious Diseases. 2006, Elsevier BV. p. 428-435.
- Phillips, R., et al., Sensitivity of PCR Targeting the IS2404 Insertion Sequence of Mycobacterium ulcerans in an Assay Using Punch Biopsy Specimens for Diagnosis of Buruli Ulcer. Journal of Clinical Microbiology, 2005. 43(8): p. 3650-3656.