Buruli ulcer
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: 1B21.20
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: 1B21.20
Buruli ulcer.
Granulomas with Langerhans giant cells, acanthosis, hyperkeratosis.
The occurrence of widespread necrosis and seeding of mycobacteria on the bones are possible. Spontaneous remission with scarring is possible.
Therapy according to Lebwohl | Evidence level |
Rifampin p.o. 10 mg/kg bw and streptomycin i.m. 15 mg/kg bw daily for-412 weeks | B |
Operative removal alone | B |
Operative removal and rifampin p.o. 10 mg/kg bw daily and ciprofloxacin p.o. 250-500 mg 2x daily for 3-6 months | B |
Rifampicin p.o. 10 mg/kg bw/d and clarithromycin p.o. 12-15 mg/kg bw for 2-6 months and surgical measures | B |
Rifampin p.o. 10 mg/kg bw/d and moxifloxacin p.o. 400 mg 1x daily for 3-6 months | C |
Ciprofloxacin p.o. 500 mg 2x tgl. and clarithromycin p.o. 500 mg 2x tgl. for 3-6 months and surgical removal. | C |
Rifampicin 10 mg/kg bw 1x tgl. and moxifloxacin p.o. 400 mg 2x tgl. for 3-6 months and surgical removal. | C |
Hyperthermia (40°C) | C |
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