Last Updated: 2020-08-13
- Cook 1897.
- Kleinschmidt 1935.
- McCallum 1948.
- Atypical mycobacteriosis caused by Mycobacterium ulcerans.
- Infection with the atypical mycobacterium, Mycobacterium ulcerans, an obligatory pathogen
- 3. most frequent mycobacteriosis in immunocompetent persons
- Mainly found in the tropics and subtropical regions
- Pathogen: Mycobacterium ulcerans.
- Incubation time: 2-14 weeks.
- The path of infection is not clear. Possibly via contaminated soil, plants, possibly insects or from person to person.
- Painless, slightly scaly, centrally draining, partly oedematous nodules on the legs or trunk, which in the course of time develop into a size-progressive ulcer (up to 15% of KOF)
- In rare cases there is involvement of the fascia, muscles and bones
- Clinical features.
- Bact. smear
Granulomas with giant Langerhans cells, acanthosis, hyperkeratosis.
The occurrence of widespread necroses and the sowing of mycobacteria on the bones is possible. Spontaneous remission with scarring is possible.
- Meyers, W.M. and F. Portaels, Mycobacterium ulcerans Infection (Buruli Ulcer), in Tropical Infectious Diseases. 2006, Elsevier BV. p. 428-435.
- Phillips, R., et al., Sensitivity of PCR Targeting the IS2404 Insertion Sequence of Mycobacterium ulcerans in an Assay Using Punch Biopsy Specimens for Diagnosis of Buruli Ulcer. Journal of Clinical Microbiology, 2005. 43(8): p. 3650-3656.