Chronic discoid lupus erythematosus (CDLE)
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: EB51.0
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: EB51.0
Cazenave (Paris), 1844
Integumentary lupus erythematosus, lupus erythematosus chronicus discoides, lupus erythematosus chronicus, discoid lupus erythematosus (DLE), discoid lupus erythematosus.
Chronic cutaneous form of lupus erythematodes (LE).
UV-exposed areas.
Moderate compact ortho- and parahyperkeratosis, follicular hyperkeratosis, acanthosis or atrophy of the epidermis, hydropic degeneration of the cells of the stratum basale, necrotic/apoptotic keratinocytes in the basal epidermis (colloid bodies), oedema in the upper corium, interfaced dermatitis, widened PAS-positive basement membrane, periadnexal and perivascular lymphocytic infiltrates.
Direct immunofluorescence: In affected, but not in unaffected skin, a positive lupus band test with IgG, IgM, IgA, C1 and C3 is found.
The disseminated form more often progresses to SLE than the localised form.
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