Lyme borreliosis (disseminated and late infection)
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: 1C1G.1Z
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: 1C1G.1Z
Disseminated and late infection of Lyme disease.
3 stages
Plasma cell-rich, perivascular infiltrates are typical.
Early therapy is important!
Therapy according to Lebwohl |
Evidence level |
Early stage |
|
Doxycycline p.o. 100 mg 2x daily for 14 days |
A |
Amoxicillin p.o. 500 mg 3x daily for 14 days |
A |
Cefuroxime p.o. 500 mg 2x daily for 14 days |
A |
In case of neurological symptoms |
|
Cefuroxime i.v. 2g daily for 14 days |
B |
Penicillin G i.v. 18-24 million IU daily (in 4 ED) for 14 days |
B |
In case of cardiological symptoms |
|
Both oral and intravenous therapy (see.o. possible) |
C |
Lyme arthritis without neurological involvement |
|
Doxycylcline p.o. 100 mg 2x daily for 14 days |
|
Amoxicillin 500 mg 3x daily for 14 days |
|
Lyme arthritis with neurological symptoms |
|
Ceftriaxone 2 g i.v. daily for 2-3 weeks
|
B |
Penicillin G 18-24 mIU i.v. (in 4 ED) for 2-3 weeks |
|
Chron.-.Recurrent arthritides |
|
Recurrent antibiotic therapy for 28 days |
D |
Late manifestation of neurological symptoms |
|
Ceftriaxone 2 g i.v. daily for 2-3 weeks |
B |
Penicillin G 18-24 million IU i.v. (in 4 ED) for 2-3 weeks |
B |
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