Papular-purpuric-gloves-and-socks syndrome

Last Updated: 2022-03-25

Author(s): Anzengruber F., Navarini A.

ICD11: EA11

Harms et al. 1990.

Glove Sock Syndrome.

Viral exanthema with skin involvement of hands, feet and mucous membranes.

  • Mostly occurring in young adulthood
  • Seasonal peak incidence in spring and summer
  • Incubation period: 6-14 days

The syndrome is associated with parvovirus B19, coxsackie, cytomegalovirus, Epstein-Barr, measles, HIV, rubella and hepatitis B virus.

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  • In addition to moderately high fever, there is lymphadenopathy, arthralgia, myalgia and loss of appetite
  • Multiple, pruritic, livid red papules arranged glove-like on the hands and sock-like on the feet. After 24-48 hours, there is gradual confluence of the papules and formation of oedema and oedematous erythema. Petechiae and petechial purpura may also be common. Enorally, vesicles, aphthae and erosions are visible.
  • Contagiousness exists before and during the onset of exanthema

  • Clinical
  • The blood count is non-specific
  • Direct pathogen detection by PCR or antigen test

  • Self-limiting course
  • Healing without complications after 1-2 weeks

  • Symptomatic therapy
  • Mometasone fuorate 1x daily

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  3. Vargas-Diez, E., et al., Papular-purpuric gloves-and-socks syndrome. Int J Dermatol, 1996. 35(9): p. 626-32.
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  7. Gajinov, Z., et al., [Papular-purpuric gloves and socks syndrome--a case report]. Med Pregl, 2006. 59(7-8): p. 380-3.
  8. Sklavounou-Andrikopoulou, A., et al., Oral manifestations of papular-purpuric 'gloves and socks' syndrome due to parvovirus B19 infection: the first case presented in Greece and review of the literature. Oral Dis, 2004. 10(2): p. 118-22.