Last Updated: 2022-03-25
Harms et al. 1990.
Glove Sock Syndrome.
Viral exanthema with skin involvement of hands, feet and mucous membranes.
- Mostly occurring in young adulthood
- Seasonal peak incidence in spring and summer
- Incubation period: 6-14 days
The syndrome is associated with parvovirus B19, coxsackie, cytomegalovirus, Epstein-Barr, measles, HIV, rubella and hepatitis B virus..
- In addition to moderately high fever, there is lymphadenopathy, arthralgia, myalgia and loss of appetite
- Multiple, pruritic, livid red papules arranged glove-like on the hands and sock-like on the feet. After 24-48 hours, there is gradual confluence of the papules and formation of oedema and oedematous erythema. Petechiae and petechial purpura may also be common. Enorally, vesicles, aphthae and erosions are visible.
- Contagiousness exists before and during the onset of exanthema
- The blood count is non-specific
- Direct pathogen detection by PCR or antigen test
- Self-limiting course
- Healing without complications after 1-2 weeks
- Symptomatic therapy
- Mometasone fuorate 1x daily
- Fretzayas, A., et al., Papular-purpuric gloves and socks syndrome in children and adolescents. Pediatr Infect Dis J, 2009. 28(3): p. 250-2.
- Feldmann, R., M. Harms, and J.H. Saurat, Papular-purpuric 'gloves and socks' syndrome: not only parvovirus B19. Dermatology, 1994. 188(2): p. 85-7.
- Vargas-Diez, E., et al., Papular-purpuric gloves-and-socks syndrome. Int J Dermatol, 1996. 35(9): p. 626-32.
- Smith, P.T., et al., Papular-purpuric gloves and socks syndrome associated with acute parvovirus B19 infection: case report and review. Clin Infect Dis, 1998. 27(1): p. 164-8.
- Bilenchi, R., et al., Papular-purpuric "gloves and socks" syndrome. G Ital Dermatol Venereol, 2012. 147(1): p. 119-21.
- Fruhauf, J., C. Massone, and R.R. Mullegger, Bullous papular-purpuric gloves and socks syndrome in a 42-year-old female: molecular detection of parvovirus B19 DNA in lesional skin. J Am Acad Dermatol, 2009. 60(4): p. 691-5.
- Gajinov, Z., et al., [Papular-purpuric gloves and socks syndrome--a case report]. Med Pregl, 2006. 59(7-8): p. 380-3.
- Sklavounou-Andrikopoulou, A., et al., Oral manifestations of papular-purpuric 'gloves and socks' syndrome due to parvovirus B19 infection: the first case presented in Greece and review of the literature. Oral Dis, 2004. 10(2): p. 118-22.