Primary cutaneous anaplastic large cell CD30 positive lymphoma (recurrent multifocal lesions)
Last Updated: 2020-08-11
ICD11: 2B03.0
Last Updated: 2020-08-11
Author(s): Anzengruber F., Navarini A.
ICD11: 2B03.0
Stein 1985.
Clinical features
ESR/CRP, Diff.-Blood count (leukocytosis, relative lymphocytosis), liver and kidney values, LDH, electrolytes.
FACS analysis, CD4/CD8 ratio, determination of CD4+CD7 cells.
Immunoelectrophoresis, if necessary
HTLV serology, if necessary
Biopsy
Immunohistology
Molecular biology
Whole body CT, lymph node sonography, possibly PET-CT.
Anaplastic and pleomorphic cells form nodular dermal infiltrates.
5-year survival rate: 90%.
Expansion |
1st choice therapy |
2nd choice therapy |
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Stadler, R., et al., Short German guidelines: cutaneous lymphomas. J Dtsch Dermatol Ges, 2008. 6 Suppl 1: p. S25-31.
Biologicals
Brentuximab intravenously 1.8 mg/kg bw (max. 180 mg) every 3 weeks
Infusion over 30 minutes
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