Pyoderma gangraenosum
Last Updated: 2021-10-14
ICD11: EB21
Last Updated: 2021-10-14
Author(s): Anzengruber F., Navarini A.
ICD11: EB21
Brocq, 1916; Brunsting u. Goeckermann, 1930
PG, ulcerative dermatitis, Meleney ulcer, pyodermia vegetans et ulcerans gangraenosa
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Predilection sites: Extensor sides of the lower extremities, even though these are also the site of most other differentials!
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Needless debridement by surgeons when diagnosis is delayed.
Not possible before diagnosis, after diagnosis immunosuppressives should be used until the tendency to form larger ulcers has ceased.
First-line therapy: combination of ciclosporine 5 mg/day/kg bw with glucocorticoids such as prednisone 100-150 mg/day (level of evidence III).
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