Fumaric acid ester
Fumaric acid ester
blood count (BB), liver values, kidney values, U status: Application for cost assumption necessary
p.o.
30 mg p.o., weekly increase by 30 - 120mg to 720mg
6 - 8 weeks
MTX, retinoids, ciclosporin, psoralenes, kidney toxin drugs
pregnancy, lactation, renal and gastrointestinal dysfunctions, severe liver dysfunction, malignant diseases, hypersensitivity to fumaric acid esters
Gastrointestinal complaints (~60 % in the first weeks), flush -> intake in the evening with milk. Lym- phopenie -> under 500/μl dose reduction or stop. Eosinophilia -> always temporary. Abdominal cramps, flatulence
Not limited