Last Updated: 2020-11-19
Subtype of the condyloma plana. Carcinoma in situ caused by HPV 16 or 18 (rarely also HPV 31-35, 39, 42, 48, 51-54).
Young patients mostly between 20-30 years.
Pigmented, verrucous maculae and papules. In the area of the mucous membrane they appear a little brighter.
- Clinical image
- PCR with HPV typing
Genitoanal and on the mucous membranes.
Hyperplastic epidermis, mitoses, dyskeratotic keratinocytes.
- The transition to an invasive squamous cell carcinoma is estimated at approximately 1%-2.6%.
- Patients are highly infectious, partners should be examined regularly
- Frequent relapses
- Excision by laser or curette.
- Imiquimod 5% cream (off-label-use):
- Application: 5x/ week over several weeks, maximum 16 weeks
- Side effects: Redness, itching, burning, erosion of the skin. Patients should be informed about this before starting the therapy!
- With regard to the increased risk of HPV 16 and 18 carcinoma, the partner should be examined when the diagnosis is confirmed
- Wade TR. Bowenoid Papulosis of the Genitalia. Arch Dermatol 1979;115:306.
- Takayama A, Ishiguro N, Kawashima M. Coexistence of Bowenoid papulosis and Bowen's disease in a patient with systemic lupus erythematosus. J Dermatol 2012;39:646-9.
- Papadopoulos AJ, Schwartz RA, Lefkowitz A, Tinkle LL, Janniger CK, Lambert WC. Extragenital bowenoid papulosis associated with atypical human papillomavirus genotypes. J Cutan Med Surg 2002;6:117-21.
- Iwai Y, Someya K, Moriya K, Kobayakawa H, Ohyama T, Horii A. [A case of bowenoid papulosis of the penis]. Hinyokika Kiyo 1989;35:517-21.
- Deen K, Burdon-Jones D. Imiquimod in the treatment of penile intraepithelial neoplasia: An update. Australas J Dermatol 2016.
- Majores M, Bierhoff E. [Actinic keratosis, Bowen's disease, keratoacanthoma and squamous cell carcinoma of the skin]. Pathologe 2015;36:16-29.