Epidermodysplasia verruciformis
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: 1E 83
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: 1E 83
Lewandowsky u. Lutz 1922.
Verrucosis generalisata, Lewandowsky-Lutz syndrome.
Very rare HPV-induced genodermatosis with polymorphous, pronounced wart infection and increased tendency to malignant degeneration. The triggering HPV types are 5, 8, 9, 12, 14, 15, 17, 19, 20, 21-25, 36, 38, 47, 50. HPV 5 and 8 can be detected in 90% of cases.
The skin lesions mostly develop during childhood and adolescence, but can also be visible at birth. No spontaneous healing.
Solid or confluent papillomas up to the size of a cent. They are divided into 2 manifestations. On the one hand, pityriasis versicolor-like flat, yellow-red or yellow-brown papules. These appear mainly on the face and trunk. On the other hand, efflororescences appear lichenoid, wart-like on the palms. Especially the latter have a higher risk of degeneration. Often, the skin lesions occur in combination with pigment spots.
All over the integument, but mainly on the face and hands. The palms of the hands and feet can also be affected. The mucous membranes, however, are left out.
Histological findings depend on the location and duration of the disease, but generally resemble verruca plana. However, dyskeratosis and pyknotic nuclei are frequently seen.
Topical therapy
Systemic therapy (all drug therapies are off-label-use)
We Value Your Privacy!
We and our partners are using technologies like cookies and process personal data like the IP-address or browser information in order to personalize the advertising that you see. This helps us to show you more relevant ads and improves your internet experience. We also use it in order to measure results or align our website content. Because we value your privacy, we are herewith asking for your permission to use these technologies. You can always change/withdraw your consent later.