Variola vera
Last Updated: 2019-08-26
ICD11: -
Last Updated: 2019-08-26
Author(s): Anzengruber F., Navarini A.
ICD11: -
Variola; real smallpox, leaves.
Highly contagious, often lethal disease caused by Variola vera virus (= Paschen's elementary body). Extermination by the WHO was announced in 1979. If a new outbreak is suspected, it must be reported.
The host is man.
Vaccinates may have a weakened, incomplete course (Variola minor or Variolois). A further attenuated course can be seen when a modified wild-type virus (Alastrim or white pox) is infected.
Serology (specific complement binding hemagglutination inhibiting antibody).
Entire integument, especially face, extremities, acra. Some mucous membranes are also affected.
Reticular epidermal degeneration, multi-chamber intraepidermal pustules, reticulatory degeneration of the stratum spinosum, intracellular edema with the reaction products of the smallpox virus (Guarnieri body).
Pneumonia, bronchitis, encephalomyelitis, toxic myocarditis, nephritis, osteomyelitis.
If the disease has been overcome, lifetime immunity and cross-immunity against vaccinia, variola minor and cowpox exists.
Antibiosis for bacterial superinfections.
Local: Disinfectant, dehydrating measures.
Post-exposure smallpox vaccination.
Antipyretics, if necessary.
Topically, dry brushes are recommended.
Preventive vaccination should be carried out on all contact persons.
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