Blastic neoplasia of plasmacytoid dendritic cells

Last Updated: 2023-07-07

Author(s): Anzengruber F., Navarini A.

ICD11: 2A60.5

Petrella 1999

Aggressive neoplasia, which primarily starts on the skin and becomes generalised leukaemic in the course of the disease.

  • Rare
  • Peak in frequency: 70-80 y
  • Exanthematous, reddish-brown, asymptomatic plaques and nodules on the trunk and head
  • Involvement of CNS and bone marrow is typical

The average survival time is 12-14 months.

  • Polychemotherapy
  • Recurrences are the rule

  1. Angelot-Delettre, F., et al., In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to SL-401, an interleukin-3 receptor targeted biologic agent. Haematologica, 2015. 100(2): p. 223-30.
  2. Laribi, K., et al., Blastic Plasmacytoid Dendritic Cell Neoplasm: From Origin of the Cell to Targeted Therapies. Biol Blood Marrow Transplant, 2016.
  3. Kim, J.H., et al., Blastic Plasmacytoid Dendritic Cell Neoplasm: Analysis of Clinicopathological Feature and Treatment Outcome of Seven Cases. Ann Dermatol, 2015. 27(6): p. 727-37.
  4. Facchetti, F., et al., Neoplasms derived from plasmacytoid dendritic cells. Mod Pathol, 2016. 29(2): p. 98-111.

This website uses cookies!

We use cookies to tailor our content to your needs and continuously improve our website. You can decide which cookies you want to allow. Detailed information about the cookies we use can be found in our Privacy Policy and Cookie Settings. You can withdraw your consent at any time.