Condylomata plana
Last Updated: 2023-07-07
Author(s): Anzengruber F., Navarini A.
ICD11: -
HPV 16 and 18-associated precursors of intraepithelial neoplasia in the genitoanal region from vulva to cervix. Flat condylomata acuminata.
Skin-coloured, sharply demarcated, relatively flat (only subtly raised) papules and plaques with a verrucous surface.
- Clinic
- Acetic acid test 5%
Mostly at the cervix uteri and the prepuce.
- Partner should be examined by a doctor in any case!
- Inform patients about ping-pong phenomenon, which stands for re-infection by the untreated partner. Therefore, both partners should be treated at the same time!
Topical therapy (mostly off label use!)
Cryotherapy
- Application: 2x to 15 seconds.
- Note: effective, cheap, briefly uncomfortable for patients.
Immune modulators
Imiquimod
- 3x weekly for 12 weeks
- off-label use:
- Application: 5x/week for several weeks, maximum 16 weeks.
- Necessary before ablation of the wart surface.
- NWW: redness, itching, burning, erosion of the skin. Pat. to be informed about this before beginning therapy!
Podophyllin/Podophyllotoxin:
- Apply 2 times daily for 3 consecutive days. Repeat if necessary
- off-label use:
- Apply 2x daily for 3 consecutive days, protecting surrounding skin. Repeat if necessary
- KI: < 12y., open wounds, women of childbearing age, contraception recommended until 30 days after therapy, pregnancy, lactation
Sinecatechins ointment green tea extract:
- Administer 3 times daily for up to 16 weeks
Trichloroacetic acid 85% (magistral formulation):
- Application: 1x/week with cotton swab. Therapy belongs in the hands of a doctor. Also permitted during pregnancy, in case of overdose neutralisation with sodium bicarbonate solution
Removal with CO² laser/electrocautery/curette/excision:
- CAVE infectiousness! Especially with lasers and electrocautery. Always wear a face mask or goggles and a mouth guard! Smoke extraction is essential
Other therapies described:
Interferon- β gel application should be carried out for a maximum of 4 weeks.
- In Switzerland only available via foreign pharmacy.
- Germany: 0, 1 million IU/g, 5x tgl.
- Herpes Simplex Virus, in SpringerReference. Springer Science + Business Media.
- Drago, F. and A. Rebora, The New Herpesviruses. Arch Dermatol, 1999. 135(1).
- Arvin, A.M., R.J. Whitley, and K.M. Gutierrez, Herpes Simplex Virus Infections, in Infectious Diseases of the Fetus and Newborn Infant. 2006, Elsevier BV. p. 845-865.
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